CK-NAC LIQUID, 50 mL

PRINCIPLE

Creatine kinase (CK) releases creatine from phosphocreatine with the aid of ADP that is transformed in ATP. The glucose of reaction media reacts with ATP by the action of hexokinase, forming glucose-6-phosphate. This degrades to 6-phosphogluconate in the presence of glucose-6-phosphate dehydrogenase and NADP+. The reaction reduces the NADP+ to NADH and there is an Abs change.When the reaction conditions are optimum, the ΔAbs/min is directly related to the CK activity of the sample.

DIAGNOSTIC USE

Mostly, the increase of CK values is related to diseases of skeletal muscle or the heart. Values higher than usual are observed after trauma, surgery, myopathic disorders, myocardial infarction, prolonged hypothermia or hypothyroidism. Also, elevated values are described in cases of Reye syndrome or Duchenne disease.

Results lower than the reference values may reflect a sedentary lifestyle or the presence of low muscle mass.

Single test result can not be used to make a clinical diagnosis. It should integrate clinical and laboratory data.