LDH LIQUID, 125 mL

PRINCIPLE

The lactate dehydrogenase catalyzes the reduction of pyruvate with the aid of NADH as cofactor, which is oxidized to NAD+, giving an absorbance change.

In optimum reaction conditions the ΔAbs/min is directly related to LDH concentration in the sample.

DIAGNOSTIC USE

Increased levels of LDH in serum are found in patients suff ering from hepatitis, infectious mononucleosis, malignant tumours, pancreatitis, cirrhosis, or myocardial infarction, due to release of enzyme from the tissue. Values also increase in cases of muscular dystrophy or anemias. Values below the usual are not clinically significant.

Single test result could not be used to make a clinical diagnosis. It should integrate clinical and laboratory data.